Oncometabolite 2-hydroxyglutarate destabilizes CDH1 to regulate quiescence and enhance chemotherapy sensitivity
Hai-Hui Zhang, Xiang-Tian Chen, Si-Qi Li, Xin-Lei Yan, Meng Wang, Yan Lin, Yi-Yuan Yuan, Yun-Zi Mao, Jie Liu, Wei Xu · 2026
Read Oncometabolite 2-hydroxyglutarate destabilizes CDH1 to regulate quiescence and enhance chemotherapy sensitivity by Hai-Hui Zhang, Xiang-Tian Chen, Si-Qi Li, Xin-Lei Yan, Meng Wang, Yan Lin, Yi-Yuan Yuan, Yun-Zi Mao, Jie Liu, Wei Xu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13474960.txt.
Description
Hai-Hui Zhang and colleagues explain in 2026 why a gene fault linked to better cancer outcomes may help chemo work. The fault makes a waste product called 2-HG build up in tumor cells. That product blocks a helper enzyme that normally steadies a cell-cycle brake called CDH1. Without steadying, the brake gets marked and destroyed by the cell.
With the brake gone, fewer tumor cells rest in a quiet state that shrugs off chemo. Tests in brain, lung, and bowel tumor cells all showed the same sensitizing effect. Animal work matched the lab pattern. The waste product itself, or mimics of it, could become chemo partners.
Catalog record
| CREATOR | Hai-Hui Zhang, Xiang-Tian Chen, Si-Qi Li, Xin-Lei Yan, Meng Wang, Yan Lin, Yi-Yuan Yuan, Yun-Zi Mao, Jie Liu, Wei Xu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 80804 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |