Spatiotemporal heterogeneity of neutrophil extracellular traps in hepatocellular carcinoma microenvironment and targeted therapy progress
Ying Zheng, Ganggang Jia, Bin Li, Chuyi Li, Jiucong Zhang, Xiaohui Yu · 2026
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Description
Zheng and co-authors review neutrophil extracellular traps in liver cancer in 2026, focusing on how these web-like structures vary across a tumor and over time. The traps, called NETs, are strands of DNA and enzymes that white blood cells cast out, normally to catch germs. In hepatocellular carcinoma, the commonest liver cancer, the review argues these webs form a shifting barrier that helps tumors resist treatment.
The scale of the disease frames the review, since this cancer type makes up 75 to 85 percent of primary liver cancers worldwide. Hepatitis B and C infections account for about 80 percent of cases, and tumors return in up to 88 percent of patients even after curative treatment, the authors note. Response to immune checkpoint drugs stays under 20 percent, and the review links NET-driven immune-excluding zones to that resistance, then surveys drugs aimed at dismantling the traps.
Catalog record
| CREATOR | Ying Zheng, Ganggang Jia, Bin Li, Chuyi Li, Jiucong Zhang, Xiaohui Yu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 94 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |