Tubulin-tyrosine ligase-like protein 12(TTLL12): elevated expression in oral squamous cell carcinoma and its clinical prognostic implications
Yu-lu Wang, Yi-run Wang, Lin-sheng Dong, Ya-dong Li · 2026
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Description
Yu-lu Wang and three colleagues examined in 2026 whether a protein called TTLL12 marks aggressive mouth cancer. They measured it in 162 oral squamous cell carcinoma samples and 30 nearby normal samples from patients operated on between 2014 and 2018.
TTLL12 ran significantly higher in tumour tissue, and high levels tracked larger tumours, advanced stage, neck lymph node spread, and later distant spread. In adjusted analysis it stood as an independent predictor of survival, and high-level patients lived significantly shorter. The authors offer TTLL12 as a candidate marker for judging prognosis in mouth cancer.
Catalog record
| CREATOR | Yu-lu Wang, Yi-run Wang, Lin-sheng Dong, Ya-dong Li |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 25 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |