The neuroprotective and therapeutic potential of resveratrol for traumatic spinal cord injuries: a systematic review
Mariam Moselmani, Dana Khayat, Sara Ajami, Aya Mansour, Ghina Rammal, Nada Alaaeddine · 2026
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Description
Moselmani and colleagues reviewed animal and lab evidence in 2026 on resveratrol, a plant compound in grape skins, as a treatment for traumatic spinal cord injury. No drug yet reliably protects the cord after a crash or fall, and damage keeps spreading for days through inflammation and cell death. The team searched four databases for studies from 2015 to 2025 that tested resveratrol after cord injury.
The search found 456 candidate studies, and only eight met the review's standards for close reading and quality checks. Across those eight, resveratrol consistently improved movement recovery in injured animals, preserved more motor neurons, and boosted autophagy, the cell's recycling system, after injury. It also dampened cell suicide, inflammation, oxidative stress, and an iron-driven cell death called ferroptosis, so the authors call for stronger animal work and early human trials next.
Catalog record
| CREATOR | Mariam Moselmani, Dana Khayat, Sara Ajami, Aya Mansour, Ghina Rammal, Nada Alaaeddine |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 61 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |