Current evidence and future perspectives in the treatment of head and neck vagal paragangliomas: a systematic review
Lara Valentina Comini, Andrea Rampi, Emilio Salerno, Paola Lovino Camerino, Alex Finco, Gabriele Redaelli, Davide Di Santo, Stefano Bondi · 2026
Read Current evidence and future perspectives in the treatment of head and neck vagal paragangliomas: a systematic review by Lara Valentina Comini, Andrea Rampi, Emilio Salerno, Paola Lovino Camerino, Alex Finco, Gabriele Redaelli, Davide Di Santo, Stefano Bondi (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13474853.txt.
Description
Comini and co-authors reviewed treatment results in 2026 for vagal paragangliomas, rare nerve-related tumors of the neck that usually grow slowly but can invade nearby tissue. Care is contested, since removing the tumor often damages the vagus nerve it grows on, while watching it risks unchecked growth. The team gathered every usable published series to compare surgery, radiotherapy, combined care, and observation.
Across 41 articles covering 501 patients, 325 had surgery, 101 had radiotherapy, 9 had both, and 66 were simply observed over time. Surgery removed tumors reliably but almost always injured the vagus nerve, causing voice and swallowing problems, and impairment of at least one more nerve rose 2.6-fold after operations in the data. Radiation methods controlled tumors well with milder side effects, and the authors stress that the evidence base stays weak and low in quality.
Catalog record
| CREATOR | Lara Valentina Comini, Andrea Rampi, Emilio Salerno, Paola Lovino Camerino, Alex Finco, Gabriele Redaelli, Davide Di Santo, Stefano Bondi |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 38 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |