Klf4-Tymp axis promotes inflammation-driven early tumorigenesis by enhancing kras mutation-induced acinar-to-ductal metaplasia through Pi3k/Akt and Mek/Erk pathways
Qihang Yuan, Junhong Chen, Peng Luo, Kai Liu, Fangyue Guo, Yao Xu, Mengying Tong, Hong Xiang, Dong Shang · 2026
Read Klf4-Tymp axis promotes inflammation-driven early tumorigenesis by enhancing kras mutation-induced acinar-to-ductal metaplasia through Pi3k/Akt and Mek/Erk pathways by Qihang Yuan, Junhong Chen, Peng Luo, Kai Liu, Fangyue Guo, Yao Xu, Mengying Tong, Hong Xiang, Dong Shang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13474847.txt.
Description
Qihang Yuan and co-authors study a gene pair that drives an early step toward pancreatic cancer, in a 2026 paper. The early step is a change where enzyme-making cells turn into duct-like cells. That change can be undone in a healthy pancreas, but with a Kras mutation and inflammation it can move on toward cancer. The team want to map which cells take part and what controls the switch.
They gather single-cell data from 146 human pancreas samples and use machine learning to track how the cell mix shifts. Other data types point to a pair of genes, Klf4 and Tymp, tied to the switch. A lab test shows the first gene can switch on the second. Gene silencing in live tissue is used to test the chain further.
Catalog record
| CREATOR | Qihang Yuan, Junhong Chen, Peng Luo, Kai Liu, Fangyue Guo, Yao Xu, Mengying Tong, Hong Xiang, Dong Shang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 65 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |