An epithelial cell fate-driven predictive model for liver metastasis risk in primary colorectal cancer through single-cell and multi-omics integration
Min Yin, Xiaochen Bo, Yaoyao Li, Simin Yu, Zhijie Lin, Mei Wang, Jian Wu, Ming Zhou, Lingmin Kong, Yefei Zhu, Weiming Xiao, Yanbing Ding · 2026
Read An epithelial cell fate-driven predictive model for liver metastasis risk in primary colorectal cancer through single-cell and multi-omics integration by Min Yin, Xiaochen Bo, Yaoyao Li, Simin Yu, Zhijie Lin, Mei Wang, Jian Wu, Ming Zhou, Lingmin Kong, Yefei Zhu, Weiming Xiao, Yanbing Ding (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13474844.txt.
Description
Yin and colleagues built a model in 2026 to predict which bowel cancers are likely to spread to the liver. The model uses the fate of epithelial cells, the surface cells where these tumors begin. They profiled single cells from paired tumor and liver samples, derived a gene signature of cell states, and applied it to 433 primary tumors in a large public cancer cohort. Three risk groups emerged from the clustering analysis.
One group, labeled growth-inhibited, had the best survival outlook, while the aggressive group enriched for TP53 mutations fared worst in the cohort studied. The team checked the model further in tissue from 45 patients and in lab experiments centered on a marker gene called HSPA1A. Switching that gene off in cancer cells weakened their invasion in dishes and reduced spread in animal models, supporting its role in the aggressive pattern the model flags.
Catalog record
| CREATOR | Min Yin, Xiaochen Bo, Yaoyao Li, Simin Yu, Zhijie Lin, Mei Wang, Jian Wu, Ming Zhou, Lingmin Kong, Yefei Zhu, Weiming Xiao, Yanbing Ding |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 103 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |