Searching for new candidates for antimalarial therapy: physicochemical and in vitro evaluation of gold(I) and silver(I) N-heterocyclic carbene complexes
William Castro, Hector R Rangel, Liseth Garibaldi, Wilma Rojas-Campos, Antonio José Hernández, Joe Berroteran, Oriel Sanchez-Velasco, María Cristina Goite, Miguel A Díaz, David Coll, Mariana Hidalgo · 2026
Read Searching for new candidates for antimalarial therapy: physicochemical and in vitro evaluation of gold(I) and silver(I) N-heterocyclic carbene complexes by William Castro, Hector R Rangel, Liseth Garibaldi, Wilma Rojas-Campos, Antonio José Hernández, Joe Berroteran, Oriel Sanchez-Velasco, María Cristina Goite, Miguel A Díaz, David Coll, Mariana Hidalgo (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13474834.txt.
Description
William Castro and a broad team test metal-based compounds in 2026 as candidates against malaria. Parasites that resist standard drugs keep spreading, which drives the search for new chemical families. Two metal compounds plus their base unit were tried on two parasite strains, one drug-sensitive and one drug-resistant. Checks also covered harm to human cells and binding to blood and parasite targets.
Potency looked alike on both strains, a good sign against resistance. The compounds also touched several targets tied to parasite survival, from oxygen radicals to blood proteins. Fat-solubility and drug-like traits were measured beside potency. Early results justify animal-stage work, not yet claims of a cure.
Catalog record
| CREATOR | William Castro, Hector R Rangel, Liseth Garibaldi, Wilma Rojas-Campos, Antonio José Hernández, Joe Berroteran, Oriel Sanchez-Velasco, María Cristina Goite, Miguel A Díaz, David Coll, Mariana Hidalgo |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 60396 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |