Clinical application of an Asian Screening Array-based preimplantation genetic testing workflow for various genetic disorders
Cuiting Peng, Jun Ren, Fan Zhou, Han Chen, Hong Yang, Yutong Li, Yuezhi Keqie, Xu Zhao, Zhushu Liu, Ting Hu, Xuemei Zhang, Taoli Ding, Ji Yang, Shan Luo, Wei Fan, Xinlian Chen, Shanling Liu · 2026
Read Clinical application of an Asian Screening Array-based preimplantation genetic testing workflow for various genetic disorders by Cuiting Peng, Jun Ren, Fan Zhou, Han Chen, Hong Yang, Yutong Li, Yuezhi Keqie, Xu Zhao, Zhushu Liu, Ting Hu, Xuemei Zhang, Taoli Ding, Ji Yang, Shan Luo, Wei Fan, Xinlian Chen, Shanling Liu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13474828.txt.
Description
Peng and colleagues report clinical results in 2026 for a workflow that tests IVF embryos for single-gene diseases before transfer. The workflow rests on the Asian Screening Array, a chip reading hundreds of thousands of DNA markers. The goal is to stop parents who carry a harmful variant from passing it to a child. Their method combines family linkage analysis, which tracks which chromosome copy an embryo inherited, with direct checks of the exact mutation.
The team reviewed 377 families in preclinical work-up and 367 treatment cycles covering 1,677 embryos tested with the array-based workflow at their center. Marker density near target genes proved sufficient for linkage in most cases, and custom direct tests confirmed the array calls where they were used. After linkage and chromosome screening, 636 embryos were cleared as suitable for transfer, and long-read sequencing beat single-sperm typing for families lacking relatives' samples.
Catalog record
| CREATOR | Cuiting Peng, Jun Ren, Fan Zhou, Han Chen, Hong Yang, Yutong Li, Yuezhi Keqie, Xu Zhao, Zhushu Liu, Ting Hu, Xuemei Zhang, Taoli Ding, Ji Yang, Shan Luo, Wei Fan, Xinlian Chen, Shanling Liu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 43 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |