Amplified aggregation-induced emission via donor-acceptor-donor molecular architecture: a high-sensitivity lateral flow immunoassay platform
Xuekun Bai, Hong Zhang, Rui Zhang, Zhanxu Liu, Wei Pang, Zefeng Mao, Zesheng Liu, Huanying Zhou, Zhixian Gao · 2026
Read Amplified aggregation-induced emission via donor-acceptor-donor molecular architecture: a high-sensitivity lateral flow immunoassay platform by Xuekun Bai, Hong Zhang, Rui Zhang, Zhanxu Liu, Wei Pang, Zefeng Mao, Zesheng Liu, Huanying Zhou, Zhixian Gao (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13474791.txt.
Description
Bai and colleagues built brighter glow-in-the-dark marker molecules in 2026 for strip tests like the ones used in rapid home diagnostics. They compared a simple donor-acceptor molecule called TPB with a donor-acceptor-donor version called BTB, where donor and acceptor parts pass electric charge inside the molecule. Trapping BTB inside tiny plastic beads limited its movement and made it shine more strongly when clumped together.
In solid form, BTB reached a quantum yield of 16.52 percent, a measure of how much light energy comes back out as glow, beating TPB on the same test. Beads loaded with BTB detected the sleep hormone melatonin down to 1.82 nanograms per milliliter in samples, a limit well below the bead test using gold particles. The authors say the design rules should help build sensitive strip tests for other targets too.
Catalog record
| CREATOR | Xuekun Bai, Hong Zhang, Rui Zhang, Zhanxu Liu, Wei Pang, Zefeng Mao, Zesheng Liu, Huanying Zhou, Zhixian Gao |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 37 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |