Mitochondrial metabolic reprogramming drives diabetic kidney disease progression: cell-specific mechanisms, metabolic memory, and targeted strategies
Lingfei Zhang, Yue Zhang, Liu Han, Jialei Wang, Lijie Hou, Songbo Fu · 2026
Read Mitochondrial metabolic reprogramming drives diabetic kidney disease progression: cell-specific mechanisms, metabolic memory, and targeted strategies by Lingfei Zhang, Yue Zhang, Liu Han, Jialei Wang, Lijie Hou, Songbo Fu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13474777.txt.
Description
Lingfei Zhang and colleagues review in 2026 how cell power plants reshape their fuel use in diabetic kidney disease. That disease is the top cause of long-term kidney failure worldwide. The review covers kidney and immune cell types one by one, since each handles fuel in its own way. A key thread is metabolic memory, where past high sugar keeps harming cells after sugar falls.
Chemical marks on genes and proteins help store that memory, and power plants sit at the center of the marks. Care ideas range from lab-stage compounds to drugs already in clinic use. Each is judged on how it resets fuel handling. Joining fuel science with gene-mark science opens fresh routes past current care limits.
Catalog record
| CREATOR | Lingfei Zhang, Yue Zhang, Liu Han, Jialei Wang, Lijie Hou, Songbo Fu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 76316 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |