Bridging gut microbiota and polycystic ovary syndrome: the mediating role of metabolites and immune pathways via Mendelian randomization and mediation analysis
Yushan Li, Yan Zhang, Wei Liu, Tao Tao · 2026
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Description
Yushan Li and colleagues use gene-based causal tools in 2026 to trace how gut microbes may shape polycystic ovary syndrome. That syndrome is a common hormone and metabolic disorder in women of childbearing age. Public gene study data fed a two-step design that tests microbe effects on blood chemicals, immune cells, and inflammation proteins first. Those middle factors were then tested against the syndrome.
Eleven microbe groups showed causal links to the syndrome in the first pass. Mediation math traced part of their effect through the middle factors. Checks with several backup methods guarded against false signals. The work maps routes by which gut care might one day ease the syndrome.
Catalog record
| CREATOR | Yushan Li, Yan Zhang, Wei Liu, Tao Tao |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 37933 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |