Association of testosterone and sex hormone–binding globulin with chronic liver disease outcomes across sex and menopausal status
Luna Liu, Wenhui Liu, Yingzhou Shi, Xiaoran Cha, Panpan Yin, Qingbo Guan, Xiude Fan, Mo Wang · 2026
Read Association of testosterone and sex hormone–binding globulin with chronic liver disease outcomes across sex and menopausal status by Luna Liu, Wenhui Liu, Yingzhou Shi, Xiaoran Cha, Panpan Yin, Qingbo Guan, Xiude Fan, Mo Wang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13474746.txt.
Description
Luna Liu and seven colleagues studied in 2026 whether testosterone and sex hormone-binding globulin levels track chronic liver disease outcomes, using UK Biobank data. They followed about 156,000 men, 79,600 postmenopausal women, and 28,200 premenopausal women for a median of about thirteen and a half years.
Men faced the highest risk overall. Men in the top quarter for SHBG had markedly higher hazards for fibrosis and cirrhosis, liver cancer, and liver-related death than men in the bottom quarter. Top-quarter testosterone showed a similar, weaker pattern. Postmenopausal women showed weaker SHBG links only, and premenopausal women showed none. The authors stress that causality and mechanisms still need study.
Catalog record
| CREATOR | Luna Liu, Wenhui Liu, Yingzhou Shi, Xiaoran Cha, Panpan Yin, Qingbo Guan, Xiude Fan, Mo Wang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 54 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |