Methylation-based biomarkers from thin-prep cytology test samples for early detection of cervical cancer: application and clinical potential
Zhihan Liu, Guorong Liu, Shuanping Liu, Xiuxiu Wang, Yunshi Liang, Yuanyuan Guo, Baochen Du, Nabo Miao, Wenli Shi, Qiuyun Zhu, Liping Yu, Cui Deng, Guo Chen, Lijuan Huang, Lingling Zhan, Xiangyu Zheng, Jie Zhao, Yongjun Li, Xiaoliang Han, Yang Cheng, Jing Yang · 2026
Read Methylation-based biomarkers from thin-prep cytology test samples for early detection of cervical cancer: application and clinical potential by Zhihan Liu, Guorong Liu, Shuanping Liu, Xiuxiu Wang, Yunshi Liang, Yuanyuan Guo, Baochen Du, Nabo Miao, Wenli Shi, Qiuyun Zhu, Liping Yu, Cui Deng, Guo Chen, Lijuan Huang, Lingling Zhan, Xiangyu Zheng, Jie Zhao, Yongjun Li, Xiaoliang Han, Yang Cheng, Jing Yang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13474730.txt.
Description
Zhihan Liu and a large team of co-authors build blood-free markers for early cervical cancer from the samples already taken in screening. Standard screening uses virus testing and a cell test, but both miss cases or flag harmless ones. DNA methylation, small chemical tags on genes, can shift early in cancer. Their 2026 study hunted for tag patterns in stored tissue and in the fluid left from routine cell tests in a Chinese group. The goal was a marker set that works on the screening sample itself.
A test that runs on the same sample saves a second visit and extra cost. The team checked the markers' power to split cancer and near-cancer from healthy results. They present the approach as a path to catch more cases early, when treatment works best, without new sampling.
Catalog record
| CREATOR | Zhihan Liu, Guorong Liu, Shuanping Liu, Xiuxiu Wang, Yunshi Liang, Yuanyuan Guo, Baochen Du, Nabo Miao, Wenli Shi, Qiuyun Zhu, Liping Yu, Cui Deng, Guo Chen, Lijuan Huang, Lingling Zhan, Xiangyu Zheng, Jie Zhao, Yongjun Li, Xiaoliang Han, Yang Cheng, Jing Yang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 41 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |