Paying for precision: funding approaches for N-of-1 trials of individualized gene targeted therapies
Nicole Nolen, Annemieke Aartsma-Rus, Christine Caneva, Curtis R. Coughlin II, Margot A. Cousin, Catherine Douthwright, Holm Graessner, Olivia Kim-McManus, Ashley Kuniholm, Stefanie Leonard, Andrea Martinsen, Margaret Meserve, Matthis Synofzik, Booma Yandava, Timothy W. Yu, Scott Demarest, Roger J. P · 2026
Read Paying for precision: funding approaches for N-of-1 trials of individualized gene targeted therapies by Nicole Nolen, Annemieke Aartsma-Rus, Christine Caneva, Curtis R. Coughlin II, Margot A. Cousin, Catherine Douthwright, Holm Graessner, Olivia Kim-McManus, Ashley Kuniholm, Stefanie Leonard, Andrea Martinsen, Margaret Meserve, Matthis Synofzik, Booma Yandava, Timothy W. Yu, Scott Demarest, Roger J. P (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13474725.txt.
Description
For a handful of children with unique gene faults, scientists can now craft a treatment for one patient alone, but who pays for such N-of-1 trials is unresolved. Nicole Nolen and co-authors map the funding question in this 2026 report.
They review past funding models, the role insurers might play, and the practical and ethical hurdles that surround paying for a therapy built for a single person. Administrative friction and high unit costs stand out as the main brakes. The authors aim to give researchers, families, and payers a shared picture of workable routes, so promising one-off treatments do not stall for money alone.
Catalog record
| CREATOR | Nicole Nolen, Annemieke Aartsma-Rus, Christine Caneva, Curtis R. Coughlin II, Margot A. Cousin, Catherine Douthwright, Holm Graessner, Olivia Kim-McManus, Ashley Kuniholm, Stefanie Leonard, Andrea Martinsen, Margaret Meserve, Matthis Synofzik, Booma Yandava, Timothy W. Yu, Scott Demarest, Roger J. P |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 45 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |