Phenotype and molecular characterization of K1-ST700 hypervirulent Klebsiella pneumoniae isolated from bone marrow aspirate of a patient with multi-system infection
Chunhong Shao, Xia Chen, Tingchao Wu, Wenyang Wang, Yan Wang, Meijie Jiang · 2026
Read Phenotype and molecular characterization of K1-ST700 hypervirulent Klebsiella pneumoniae isolated from bone marrow aspirate of a patient with multi-system infection by Chunhong Shao, Xia Chen, Tingchao Wu, Wenyang Wang, Yan Wang, Meijie Jiang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13474677.txt.
Description
Shao and co-authors characterized a hypervirulent Klebsiella pneumoniae strain cultured from the bone marrow of a 53-year-old man with type 2 diabetes, an almost unheard-of isolation site for this pathogen. Their 2026 study compared four matched isolates from his bone marrow, blood, liver abscess, and lung fluid, confirming all as the K1-ST700 lineage by typing and whole-genome sequencing.
Every isolate proved highly lethal in mouse infection models yet remained susceptible to all antibiotics tested, a reminder that virulence, not resistance, drove the man's rapid multiple-organ failure. His labs told the severity plainly: platelets had crashed to 7 billion per liter and procalcitonin, an infection marker, hit 17.83 against a normal ceiling under 0.5 in the reported units. Background mortality for such infections runs 28.4% at thirty days and 42% once invasive.
Catalog record
| CREATOR | Chunhong Shao, Xia Chen, Tingchao Wu, Wenyang Wang, Yan Wang, Meijie Jiang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 24 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |