Context-dependent toxicity of human tau isoforms in a Drosophila tauopathy model
Yelena Ivanova, Miguel Ramirez-Moreno, Jie Liu, Leila Abtahi, Baidong Wu, Amber S. Cooper, Zengbo Wang, Douglas W. Allan, Amritpal Mudher, Aaron A. Comeault, Lovesha Sivanatharajah · 2026
Read Context-dependent toxicity of human tau isoforms in a Drosophila tauopathy model by Yelena Ivanova, Miguel Ramirez-Moreno, Jie Liu, Leila Abtahi, Baidong Wu, Amber S. Cooper, Zengbo Wang, Douglas W. Allan, Amritpal Mudher, Aaron A. Comeault, Lovesha Sivanatharajah (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13474566.txt.
Description
Yelena Ivanova and colleagues test each human tau form for harm in fruit flies in a 2026 study. Tau is a brain protein that piles up in a group of diseases that erode memory and movement. Humans make six tau forms, split by whether they carry three or four grip segments. Fly lines were built so each form sat in the exact same gene spot for fair comparison.
Harm depended on where and when a form was switched on, not just on how much was present. Four-grip forms were broadly more harmful than three-grip forms. Some nerve cells fell early and kept falling, while hardier cells failed only late in life. Cell setting, not protein amount alone, shapes tau harm.
Catalog record
| CREATOR | Yelena Ivanova, Miguel Ramirez-Moreno, Jie Liu, Leila Abtahi, Baidong Wu, Amber S. Cooper, Zengbo Wang, Douglas W. Allan, Amritpal Mudher, Aaron A. Comeault, Lovesha Sivanatharajah |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 48 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |