Novel 6-aryl-1-(3,4,5-trimethoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine derivatives: design, synthesis, and biological evaluation as potent tubulin polymerisation inhibitors with anticancer activity
Jiake Gao, Yujing Zhang, Rui Qu, Qianqian Xu, Zhenjuan Sun, Liya Cui, Chao Wang · 2026
Read Novel 6-aryl-1-(3,4,5-trimethoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine derivatives: design, synthesis, and biological evaluation as potent tubulin polymerisation inhibitors with anticancer activity by Jiake Gao, Yujing Zhang, Rui Qu, Qianqian Xu, Zhenjuan Sun, Liya Cui, Chao Wang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13474524.txt.
Description
Jiake Gao and six co-authors designed a new family of cancer drug candidates that attack the cell's inner scaffolding, in a 2026 study. The scaffolding, built from tubulin, is needed for cell division, and drugs that jam it are a proven route to new cancer care. The team shaped their compounds to fit a known pocket on tubulin.
They built the new compounds and tested them on cancer cell lines. The best one, called 9t, stopped cell growth at very low doses across the lines tested. It did little harm to normal cells, which gave it a wide safety margin. Lab assays showed it blocks scaffold building, wrecks the scaffold inside cells, halts division, and triggers cell death. The authors present it as a strong lead for further preclinical work.
Catalog record
| CREATOR | Jiake Gao, Yujing Zhang, Rui Qu, Qianqian Xu, Zhenjuan Sun, Liya Cui, Chao Wang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 58 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |