Application of the “oral simulated tube feeding method” in enteral nutrition for patients with moderately severe acute pancreatitis: a randomized controlled non-inferiority trial comparing the nasogastric feeding route

Description

Shi and colleagues trialled in 2026 an oral simulated tube feeding method against nasogastric feeding in acute pancreatitis. Sixty patients with moderately severe disease were randomised: thirty-one to the oral simulated method, twenty-nine to a nose-to-stomach tube. Feeding tolerance at twenty-four hours was the main outcome, in a non-inferiority design testing whether the new method is no worse.

The oral method's tolerance rate was about ninety-seven percent, versus about sixty-nine percent for tube feeding, comfortably non-inferior. Tolerance scores were also better, and bloating and nausea occurred less often. Hospital costs were significantly lower with the oral method: only about thirteen percent of its patients exceeded the cost threshold, versus about half of tube patients. Length of stay did not differ. The authors conclude the oral simulated method is a safe, cheaper alternative for these patients.

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Source: https://europepmc.org/article/MED/PMC13474502