Efficacy and safety of microneedling with tranexamic acid versus microneedling with vitamin C in the treatment of melasma: a systematic review and meta-analysis
Thanapon Roddaje, Sinitta Saowarat, Phawit Norchai · 2026
Read Efficacy and safety of microneedling with tranexamic acid versus microneedling with vitamin C in the treatment of melasma: a systematic review and meta-analysis by Thanapon Roddaje, Sinitta Saowarat, Phawit Norchai (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13474404.txt.
Description
Thanapon Roddaje and two colleagues compared in 2026 microneedling with tranexamic acid against microneedling with vitamin C for melasma, a common pigment disorder. They pooled eight studies with 232 patients, harmonising severity scores across designs and depths, following standard review guidelines.
The pooled difference was not statistically significant, and subgroup results by needle depth, design, and follow-up were too weak to confirm any interaction. Both options looked well tolerated over 6 to 16 weeks, with only mild, brief side effects. Long-term safety and recurrence remain unknown, and the authors warn that a non-significant result does not prove the two treatments equal.
Catalog record
| CREATOR | Thanapon Roddaje, Sinitta Saowarat, Phawit Norchai |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 41 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |