Focused Update to International Consensus Recommendations for the Use of Prolonged‐Infusion Beta‐Lactam Antibiotics Among Severely Ill Adult Patients: Endorsed by the American College of Clinical Pharmacy, British Society for Antimicrobial Chemotherapy, Cystic Fibrosis Foundation, European Society o
Lisa T Hong, Alireza FakhriRavari, Marta Ulldemolins, Jason A Roberts, Robert A Bonomo, Marc H Scheetz, the Prolonged‐Infusion Beta‐Lactam Consensus Panel · 2026
Read Focused Update to International Consensus Recommendations for the Use of Prolonged‐Infusion Beta‐Lactam Antibiotics Among Severely Ill Adult Patients: Endorsed by the American College of Clinical Pharmacy, British Society for Antimicrobial Chemotherapy, Cystic Fibrosis Foundation, European Society o by Lisa T Hong, Alireza FakhriRavari, Marta Ulldemolins, Jason A Roberts, Robert A Bonomo, Marc H Scheetz, the Prolonged‐Infusion Beta‐Lactam Consensus Panel (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13474301.txt.
Description
Lisa Hong and co-authors update the world's guidance on how slowly to drip a major antibiotic class into the sickest patients in a 2026 consensus paper. Beta-lactam antibiotics kill by time above a threshold, so stretching each dose over hours, prolonged infusion, should beat the standard quick drip. A 2023 consensus already leaned that way on very low certainty evidence; new trials demanded a re-vote.
Twenty-eight randomized trials on mortality pooled to a clear edge for prolonged infusion, with Bayesian analysis putting the chance of benefit near ninety-nine percent. Twenty-one trials on clinical cure agreed, favoring the slow drip by a similar margin. The update, endorsed by seven international societies across pharmacy, infectious diseases, and critical care, firms the recommendation while the methods chapter shows its work. For intensive care units, the message is operational: pumps and protocols, not new drugs.
Catalog record
| CREATOR | Lisa T Hong, Alireza FakhriRavari, Marta Ulldemolins, Jason A Roberts, Robert A Bonomo, Marc H Scheetz, the Prolonged‐Infusion Beta‐Lactam Consensus Panel |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 31 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |