Correlative study of Parnassia palustris extract on orthotopic glioma suppression and gut microbiota modulation in mice
Ruijun Wang, Huifang Li, Rile Ge, Yuanming Pan, Zhanbiao He · 2026
Read Correlative study of Parnassia palustris extract on orthotopic glioma suppression and gut microbiota modulation in mice by Ruijun Wang, Huifang Li, Rile Ge, Yuanming Pan, Zhanbiao He (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13474163.txt.
Description
Wang and colleagues tested in 2026 an extract of the plant Parnassia palustris against brain glioma in mice, while tracking gut microbes. Glioma-bearing mice received the extract by stomach tube every other day, or a control solution. Tumour growth was followed by fluorescence imaging, and brain and gut samples were analysed after treatment.
The extract significantly suppressed tumour growth on imaging and by final tumour weight. Treated tumours showed lower cell density and fewer abnormal nuclei. A key growth pathway, PI3K/Akt, was inhibited, with proliferation marker KI67 down and tumour suppressor p53 up. Gut microbe diversity itself did not change, but composition shifts accompanied the antitumour effect. The authors are careful to report correlation, not causation, between microbe changes and tumour response. They present the plant extract as a candidate worth further study.
Catalog record
| CREATOR | Ruijun Wang, Huifang Li, Rile Ge, Yuanming Pan, Zhanbiao He |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 44 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |