Mitochondrial dysfunction in sepsis-induced immunoparalysis: from immune-cell metabolic reprogramming to clinical biomarkers
Jiaxin Sun, Yuye Yang, Shiyun Long, Xinsen Zou, Chenyang Duan, Yanqing Wang · 2026
Read Mitochondrial dysfunction in sepsis-induced immunoparalysis: from immune-cell metabolic reprogramming to clinical biomarkers by Jiaxin Sun, Yuye Yang, Shiyun Long, Xinsen Zou, Chenyang Duan, Yanqing Wang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13474150.txt.
Description
Sun and colleagues reviewed in 2026 how failing mitochondria help shut down the immune system in sepsis, the body's extreme response to infection. After the first storm of sepsis, many patients slip into immunoparalysis, where defenses weaken and new infections take hold. The review places mitochondria, the cell's power plants, at the center of that decline.
Different immune cells fail in different ways: some lose the power to present germs to other cells, some crawl and kill poorly, and T cells take on a worn-out profile. The review ties these faults to energy failure, chemical imbalance, leaked danger signals from damaged mitochondria, and poor quality control of the organelles. It proposes pairing mitochondria-based blood readouts with standard immune markers to spot high-risk patients early, and lists repair strategies aimed at restoring immune strength.
Catalog record
| CREATOR | Jiaxin Sun, Yuye Yang, Shiyun Long, Xinsen Zou, Chenyang Duan, Yanqing Wang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 81 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |