Integrating cryoablation with immunotherapy in non-small cell lung cancer: mechanisms, clinical evidence, and translational barriers
Chulan Yang, Xinan Long, Yangyang Ma, Lizhi Niu · 2026
Read Integrating cryoablation with immunotherapy in non-small cell lung cancer: mechanisms, clinical evidence, and translational barriers by Chulan Yang, Xinan Long, Yangyang Ma, Lizhi Niu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13474070.txt.
Description
Yang and colleagues review in 2026 how cryoablation, freezing a tumor to kill it, might strengthen immunotherapy for non-small cell lung cancer. Advanced disease still has poor long-term outcomes, and only a minority of patients gain lasting benefit from immune checkpoint drugs alone.
Freezing destroys tumor tissue in a way that releases tumor antigens and danger signals, a process called immunogenic cell death. The review argues this can act like a vaccine made inside the body, helping T cells recognize cancer elsewhere too. Early clinical studies suggest better tumor control and survival in selected settings, but the evidence is mixed and small. The authors flag open questions on treatment order, biomarkers, technique standards, and long-term safety.
Catalog record
| CREATOR | Chulan Yang, Xinan Long, Yangyang Ma, Lizhi Niu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 57 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |