Hypoxia differentially affects coronary vessel formation during heart development
Sophie Payne, Susann Bruche, Dorota Szumska, Lucija Fleisinger, Alice Neal, Mark D Preston, Sarah De Val · 2026
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Description
Payne and colleagues used a genetic trick in 2026 to ask how low oxygen shapes the building of coronary vessels, the heart's own blood supply, during development. Rather than starve embryos of oxygen, they fixed the oxygen sensor HIF in its active state in heart muscle, mimicking hypoxia. They then read gene activity cell by cell and tracked vessel growth from each source tissue.
The mimic hearts switched on sprouting genes and expanded the pathway that drives sprouting from the heart's inner lining, and sprouting from that source grew. The vessel web from the sinus venosus, an early vein, barely changed, and its pathways stayed quiet. Early artery identity changed little, yet the assembly of mature coronary arteries ran late. The authors link the oxygen pathway directly to lining-derived sprouting and suggest it also guides how arteries come together.
Catalog record
| CREATOR | Sophie Payne, Susann Bruche, Dorota Szumska, Lucija Fleisinger, Alice Neal, Mark D Preston, Sarah De Val |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 84 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |