Systematic evaluation of the heterogeneity of topologically associating domain boundaries in a large genomic context in humans
Ying Sun, Niels Tommerup, Lars Juhl Jensen, Jan Gorodkin · 2026
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Description
Ying Sun, Niels Tommerup, Lars Juhl Jensen, and Jan Gorodkin examine how varied the borders between genome folding domains really are across the human genome, in a 2026 study. These topologically associating domains guide gene control, and their boundaries were long treated as uniform. The team gathered annotated boundaries from many cell lines and tissues and read their letter content.
Two families emerged: a GC-rich set sitting in active chromatin and an AT-rich set in quiet regions, differing in repeat content and chemical marks. Boundaries unique to one cell type were also less conserved over evolution. The authors stress that boundary diversity matters functionally.
Catalog record
| CREATOR | Ying Sun, Niels Tommerup, Lars Juhl Jensen, Jan Gorodkin |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 64 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |