Role of the Antioxidant Lycopene in Bone Health: Emphasis on the RANKL/RANK/OPG Signaling Pathway
Helia Esmaili, Nazanin Asgari, Negar Mosayeb, Sadegh Jafarnejad · 2026
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Description
Helia Esmaili and co-authors review the tomato pigment lycopene as a protector of bone in this 2026 paper. Bone stays healthy while building and breakdown stay in balance. Lycopene is a fat-loving antioxidant, a close cousin of beta-carotene.
The review centers on a signaling trio that steers bone-eating cells. Lycopene may also calm inflammatory signals and spur bone-building cells. Other paths, including a growth switch, add to its profile. Rising levels of the trio's lead signal tilt bone toward loss. A food compound that nudges that balance could aid prevention. The authors map what is known and what trials still must prove. Diet-level doses remain an open question for future studies.
Catalog record
| CREATOR | Helia Esmaili, Nazanin Asgari, Negar Mosayeb, Sadegh Jafarnejad |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 41 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |