Deficiency of G9a boosts muscle regeneration through IL13/Musclin-mediated crosstalk between macrophage and myofiber
Ying Jin, Kaiyang Zhou, Siyu Hao, Hu Yue, Haoyu Wang, Zhiyuan Liu, Yihao Zhou, Yunhao Xie, Xinran Liu, Hong Chen, Yuxia Liu, Anlin Peng, Yangkai Li, Kun Huang, Ling Zheng · 2026
Read Deficiency of G9a boosts muscle regeneration through IL13/Musclin-mediated crosstalk between macrophage and myofiber by Ying Jin, Kaiyang Zhou, Siyu Hao, Hu Yue, Haoyu Wang, Zhiyuan Liu, Yihao Zhou, Yunhao Xie, Xinran Liu, Hong Chen, Yuxia Liu, Anlin Peng, Yangkai Li, Kun Huang, Ling Zheng (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13473583.txt.
Description
Ying Jin and a large team report in 2026 that blocking an enzyme called G9a speeds muscle repair in mice. G9a tags genes to switch them off, and its levels rise in old human muscle and in hurt mouse muscle. Deleting G9a in either immune cells or muscle fibers made repair after injury run faster. The effect traced to signals passed between those two cell types.
Without G9a, immune cells released more of a helper signal called IL13, and fibers released more of a muscle signal called musclin. Each signal alone sped repair, and giving both together worked even better in tests. The cross-talk points to a drug target for muscle-wasting illness. Older adults who lose muscle with age could gain from such work.
Catalog record
| CREATOR | Ying Jin, Kaiyang Zhou, Siyu Hao, Hu Yue, Haoyu Wang, Zhiyuan Liu, Yihao Zhou, Yunhao Xie, Xinran Liu, Hong Chen, Yuxia Liu, Anlin Peng, Yangkai Li, Kun Huang, Ling Zheng |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 60472 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |