α-Linolenic acid alleviates ovalbumin-induced allergic rhinitis in mice and modulates GPR120–NF-κB signaling
Yulan Song, Fengyao Zhang, Yan Zhao, Ruofan Liu, Yan Feng · 2026
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Description
Song and co-authors fed alpha-linolenic acid, the plant omega-3 fat, to mice with experimentally induced allergic rhinitis to test its anti-allergy credentials. Their 2026 study sensitized mice with ovalbumin and treated them orally from day 21 to day 34, comparing the fat against the standard antihistamine loratadine and vehicle.
Treated mice showed fewer nasal symptoms and cleaner nasal tissue, with less mast cell crowding and fewer mucus-swollen goblet cells than untreated allergic controls. Blood markers moved the right way: allergy-driving IgE, IL-4, IL-6, and IL-1β all fell, while interferon-gamma rose in the treated groups. Tissue analysis showed the NF-κB inflammatory pathway damped and its receptor partner GPR120 raised, though the authors concede knockout proof of that mechanism is still missing.
Catalog record
| CREATOR | Yulan Song, Fengyao Zhang, Yan Zhao, Ruofan Liu, Yan Feng |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 41 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |