Loss of Brg1 prevents the progression of pulmonary hypertension by inhibiting Nrf2 expression
Wen-Di Jiang, Mei-Yang Xu, Zi-yi Chen, Qing Chen, Guo-Qing Lu, Zheng-Yu Sun, Jia-Yi Guo, Lei Wang, Ying Qian, Li Mu, Yu-Hang Wang, Ning-ning Zhang, Hong-Ju Wang, Bi Tang, Pin-Fang Kang, Wen-Juan Wu · 2026
Read Loss of Brg1 prevents the progression of pulmonary hypertension by inhibiting Nrf2 expression by Wen-Di Jiang, Mei-Yang Xu, Zi-yi Chen, Qing Chen, Guo-Qing Lu, Zheng-Yu Sun, Jia-Yi Guo, Lei Wang, Ying Qian, Li Mu, Yu-Hang Wang, Ning-ning Zhang, Hong-Ju Wang, Bi Tang, Pin-Fang Kang, Wen-Juan Wu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13473476.txt.
Description
Wen-Di Jiang and fifteen colleagues investigated in 2026 a gene regulator that may drive pulmonary arterial hypertension, a disease in which lung arteries narrow and the heart strains. Brg1, a factor that remodels chromatin, the packaging of DNA, was known to affect cell growth and death, but its role in this lung disease was untested. The team studied rats with hypertension induced by low oxygen or monocrotaline, plus artery muscle cells grown under low oxygen.
Brg1 levels ran high in both rat models. Silencing Brg1 with a viral tool lowered a stress-response factor called Nrf2 and its partner HO-1, eased resistance to cell death, and slowed disease progression. Silencing also curbed cell growth through the mTOR/P70S6K pathway in cells and in animals. A drug that blocks Nrf2 likewise slowed growth, but losing Brg1 removed that effect. The authors nominate Brg1 as a possible treatment target.
Catalog record
| CREATOR | Wen-Di Jiang, Mei-Yang Xu, Zi-yi Chen, Qing Chen, Guo-Qing Lu, Zheng-Yu Sun, Jia-Yi Guo, Lei Wang, Ying Qian, Li Mu, Yu-Hang Wang, Ning-ning Zhang, Hong-Ju Wang, Bi Tang, Pin-Fang Kang, Wen-Juan Wu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 53 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |