TA-TMA occurring after sequential CD7 CAR-T cell therapy and allogeneic hematopoietic stem cell transplantation: a case report
Jinlin Zhang, Li Ma, Xiu Liu, Yuxin An, Mohan Zhao, Mengnan Li, Xiaomei Zhang, Jile Liu, Rui Zhang, Mingfeng Zhao · 2026
Read TA-TMA occurring after sequential CD7 CAR-T cell therapy and allogeneic hematopoietic stem cell transplantation: a case report by Jinlin Zhang, Li Ma, Xiu Liu, Yuxin An, Mohan Zhao, Mengnan Li, Xiaomei Zhang, Jile Liu, Rui Zhang, Mingfeng Zhao (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13473368.txt.
Description
Zhang and colleagues reported in 2026 a dangerous clotting complication in a leukaemia patient treated with sequential cell therapy and transplant. The patient had mixed phenotype acute leukaemia and received CD7-targeted CAR-T cells, engineered immune cells, as a bridge to a donor stem cell transplant. Early after transplant, the patient developed transplant-associated thrombotic microangiopathy, where tiny clots damage small vessels and organs.
Such stepwise therapy avoids harsh pre-transplant drugs while attacking the tumour and rebuilding blood formation. But this complication is rare, life-threatening, and tied to more non-relapse deaths. The authors aim to alert clinicians to this risk. Spotting it early and acting in time, they argue, are the levers that improve outcomes. The case gives transplant teams a reference pattern: what the complication looks like in this exact treatment sequence and when it struck.
Catalog record
| CREATOR | Jinlin Zhang, Li Ma, Xiu Liu, Yuxin An, Mohan Zhao, Mengnan Li, Xiaomei Zhang, Jile Liu, Rui Zhang, Mingfeng Zhao |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 24 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |