Admission antithrombin III activity as a risk-enrichment marker for septic shock below the ISTH overt-DIC threshold
Tao Zhou, Wanying Cheng, Guohua Jiang, Xiaojin Zhang, Li Liu, Jun Wu · 2026
Read Admission antithrombin III activity as a risk-enrichment marker for septic shock below the ISTH overt-DIC threshold by Tao Zhou, Wanying Cheng, Guohua Jiang, Xiaojin Zhang, Li Liu, Jun Wu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13473283.txt.
Description
Zhou and colleagues tested in 2026 whether a clotting-related blood measure flags septic shock risk in infected patients. The team studied 1,286 adults admitted with infection, focusing on antithrombin III activity at admission. They compared it with standard scores and checked whether its report time preceded shock onset.
Among patients below the overt DIC threshold, forty-three of forty-four shock cases had antithrombin activity under eighty percent. The measure separated the groups well in that subgroup, though its positive predictive value was low at about nine percent. Most incident shock cases had the result reported before shock onset in practice. The authors describe the marker as high-sensitivity enrichment information, useful for flagging who needs watching. They warn it must not trigger escalation alone. Prospective, time-stamped validation is required before any clinical use, they conclude.
Catalog record
| CREATOR | Tao Zhou, Wanying Cheng, Guohua Jiang, Xiaojin Zhang, Li Liu, Jun Wu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 65 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |