Lactiplantibacillus plantarum AS21 Attenuates Sex‐Biased Glucose Intolerance in Aging Mice via Gut Mucosal Microbiota‐Derived Citrulline
Mengya Jia, Mengyan Chen, Hu Chen, Huiling Zhang, Ruixue Dou, Chaorui Wang, Muhammad Ishaq, Xiaoying Wei, Zitong Ding, Xusheng Guo · 2026
Read Lactiplantibacillus plantarum AS21 Attenuates Sex‐Biased Glucose Intolerance in Aging Mice via Gut Mucosal Microbiota‐Derived Citrulline by Mengya Jia, Mengyan Chen, Hu Chen, Huiling Zhang, Ruixue Dou, Chaorui Wang, Muhammad Ishaq, Xiaoying Wei, Zitong Ding, Xusheng Guo (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13473181.txt.
Description
Jia and a team in China fed in 2026 a gut germ, Lactiplantibacillus plantarum AS21, to old mice for six months, and found its help split by sex. Old males slid into poor sugar control, the pre stage of diabetes, far more than old females. Their blood had run low on citrulline, an amino acid that helps sugar work, while female blood had more than youth marks. Germ maps of the gut wall split the same way.
The fed germ fixed the males and left the females near as they were. In males it reshaped gut wall germs, raised two genes that build citrulline, and filled the blood pool back up. Sugar tests then ran near youth marks. Plain citrulline in feed copied the whole gain, with sharper insulin release after sugar. The team pitches the germ as a male aimed tool for age linked sugar slide.
Catalog record
| CREATOR | Mengya Jia, Mengyan Chen, Hu Chen, Huiling Zhang, Ruixue Dou, Chaorui Wang, Muhammad Ishaq, Xiaoying Wei, Zitong Ding, Xusheng Guo |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 68 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |