USP7 inhibition perturbs proteostasis and tumorigenesis in triple-negative breast cancer
Ahhyun Kim, Priya Gopalakrishnan, Marina Suárez-Pizarro, Claire C. Chen, Xianxi Wang, Sydney M. McCoy, Nikita Umesh, Angie Mordant, Natalie K. Barker, Laura E. Herring, Rasha T. Kakati, Philip M. Spanheimer, Michael J. Emanuele, Claudia A. Benavente · 2026
Read USP7 inhibition perturbs proteostasis and tumorigenesis in triple-negative breast cancer by Ahhyun Kim, Priya Gopalakrishnan, Marina Suárez-Pizarro, Claire C. Chen, Xianxi Wang, Sydney M. McCoy, Nikita Umesh, Angie Mordant, Natalie K. Barker, Laura E. Herring, Rasha T. Kakati, Philip M. Spanheimer, Michael J. Emanuele, Claudia A. Benavente (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13473141.txt.
Description
Ahhyun Kim and co-authors present a 2026 journal article on blocking the enzyme USP7 in triple-negative breast cancer. These tumors almost always lose the p53 guard gene, which makes them a clean test bed for USP7 roles beyond that pathway. The enzyme is broadly raised in breast cancer. The team shut it down by genes and by drugs in tumor models.
Blocking USP7 slowed tumor growth. Deep protein scans across cell lines showed shared targets in growth, genome stability, and protein housekeeping. Many proteins that fell were themselves tagging enzymes, which USP7 normally shields from self-destruction. One new target, TOPORS, ties into a DNA repair complex, hinting at a growth route.
Catalog record
| CREATOR | Ahhyun Kim, Priya Gopalakrishnan, Marina Suárez-Pizarro, Claire C. Chen, Xianxi Wang, Sydney M. McCoy, Nikita Umesh, Angie Mordant, Natalie K. Barker, Laura E. Herring, Rasha T. Kakati, Philip M. Spanheimer, Michael J. Emanuele, Claudia A. Benavente |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 77 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |