Analysis of human chorionic gonadotropin glycoforms by nano-liquid chromatography-mass spectrometry: novel strategies based on mobile phase additive and adduct dissociation
Pierre Besson-Magdelain, Christophe Chendo, Audrey Combès, Valérie Pichon, Nathalie Delaunay · 2026
Read Analysis of human chorionic gonadotropin glycoforms by nano-liquid chromatography-mass spectrometry: novel strategies based on mobile phase additive and adduct dissociation by Pierre Besson-Magdelain, Christophe Chendo, Audrey Combès, Valérie Pichon, Nathalie Delaunay (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13473069.txt.
Description
Pierre Besson-Magdelain and co-authors refine a lab method in 2026 for mapping sugar forms of a human hormone called hCG. The hormone matters in pregnancy tests and in some cancer care. Older methods gave weak signals and messy spectra because the acid used to aid separation also formed extra adducts. The team tried lower acid levels and then swapped in a milder acid.
The milder acid lifted signal strength and cut adduct share from about thirty percent to about ten percent. A scanning mode that breaks apart what is left raised signals several times over. The final setup found far more sugar forms than before, with 76 forms for one hormone part and 200 for the other. Labs gain a cleaner way to profile this hormone.
Catalog record
| CREATOR | Pierre Besson-Magdelain, Christophe Chendo, Audrey Combès, Valérie Pichon, Nathalie Delaunay |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 84387 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |