Protein phosphatase 2 phosphatase activator (PTPA) promotes oncogene-induced senescence and carboplatin response in human malignant pleural mesothelioma cells
Eleonora Nigliato, Yan Ma, Rita Derua, Maria Butyrin, Sandra P. Nunes, Léa Guilmot, Antonio De Gianni, Rüveyda Dok, Andrew P. Feld, Michael Ohlmeyer, Brian E. Wadzinski, Sandra Nuyts, Ilaria Elia, Anna Sablina, Veerle Janssens · 2026
Read Protein phosphatase 2 phosphatase activator (PTPA) promotes oncogene-induced senescence and carboplatin response in human malignant pleural mesothelioma cells by Eleonora Nigliato, Yan Ma, Rita Derua, Maria Butyrin, Sandra P. Nunes, Léa Guilmot, Antonio De Gianni, Rüveyda Dok, Andrew P. Feld, Michael Ohlmeyer, Brian E. Wadzinski, Sandra Nuyts, Ilaria Elia, Anna Sablina, Veerle Janssens (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13473063.txt.
Description
Nigliato and co-authors studied PTPA, the activator of the tumor-suppressing phosphatase PP2A, in malignant pleural mesothelioma, the asbestos-linked cancer of the lung lining. Their 2026 analysis combined cancer genome data with lab tests putting PTPA back in low-expressing mesothelioma cells.
Losing one copy of the PTPA gene was common, occurring in 26% of the 87 patients in the genome cohort, and it tracked with much shorter survival. Putting PTPA back cut colony formation and growth without anchorage, and it raised the phosphatase's activity in the treated cells. Treated cells also aged into senescence more readily under oncogene stress and responded better to carboplatin. Mesothelioma of the pleura accounts for 90% of mesothelioma cases, the authors note.
Catalog record
| CREATOR | Eleonora Nigliato, Yan Ma, Rita Derua, Maria Butyrin, Sandra P. Nunes, Léa Guilmot, Antonio De Gianni, Rüveyda Dok, Andrew P. Feld, Michael Ohlmeyer, Brian E. Wadzinski, Sandra Nuyts, Ilaria Elia, Anna Sablina, Veerle Janssens |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 78 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |