Experimental study of [68Ga]Ga-HER2-RGD, a dual-target molecular probe, for breast cancer PET/CT imaging
Xiujuan Zhao, Meng Dai, Tianyue Li, Nuo Li, Xiaolin Chen, Bo Dong, Yingxiao Guo, Mengyue Wei, Xinming Zhao, Jingmian Zhang · 2026
Read Experimental study of [68Ga]Ga-HER2-RGD, a dual-target molecular probe, for breast cancer PET/CT imaging by Xiujuan Zhao, Meng Dai, Tianyue Li, Nuo Li, Xiaolin Chen, Bo Dong, Yingxiao Guo, Mengyue Wei, Xinming Zhao, Jingmian Zhang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13473053.txt.
Description
Zhao and co-authors built a two-headed imaging probe that can latch onto either of two breast cancer markers, aiming to light up tumors that express only one of them. Their 2026 experimental study attached a HER2-binding piece and an RGD piece, which targets a vessel integrin, to a gallium-68 label for PET scanning. They tested it in three mouse tumor models.
The probe was synthesized and labeled at radiochemical purity above 95%. Cell uptake followed the receptor map: the double-high cell line took up the most probe, ahead of single-high and double-low lines. Because HER2-negative tumors make up 70 to 85% of breast cancers, a dual-target agent could rescue scans that single-target tracers miss. The authors say the probe semi-quantitatively reports receptor levels, a candidate for clinical translation.
Catalog record
| CREATOR | Xiujuan Zhao, Meng Dai, Tianyue Li, Nuo Li, Xiaolin Chen, Bo Dong, Yingxiao Guo, Mengyue Wei, Xinming Zhao, Jingmian Zhang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 29 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |