PSMD4 promotes malignant phenotypes and is associated with angiogenesis-related signaling and immune remodeling in hepatocellular carcinoma
Qiuyi Wang, Hanxuan Yang, Yanan Pang, Chanyan Zhu · 2026
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Description
Wang and co-authors examined PSMD4, a proteasome subunit that helps cells shred unwanted proteins, as a driver and marker in liver cancer. Their 2026 study trained on one international cohort and validated on another, layering survival analysis, single-cell data, spatial mapping, and knockdown experiments in two liver cancer cell lines.
PSMD4 was significantly upregulated in tumors in both cohorts. The death toll separated by its level: deceased patients made up 41% of the high-expression group versus 30% of the low group in the training cohort. The validation cohort showed 19% versus 6% across the same split. Enrichment analysis tied high PSMD4 to blood-vessel growth signaling and immune remodeling inside tumors. Silencing it in Huh7 and HepG2 cells slowed growth, colony formation, and wound closure.
Catalog record
| CREATOR | Qiuyi Wang, Hanxuan Yang, Yanan Pang, Chanyan Zhu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 36 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |