LncRNA NRAV is associated with unfavorable prognosis and immune-related transcriptional features in hepatocellular carcinoma
Xingbao Fang, Yan Cai, Zhaojun Li, Xiongbing Peng, Shaohua Yang, Zhuoyu Zhao, Yuehong Li · 2026
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Description
Fang and co-authors investigated NRAV, a long noncoding RNA, as a possible warning flag in liver cancer, combining database mining with cell experiments. Their 2026 study compared NRAV levels across cancer genome cohorts, paired tumor and normal samples, and independent validation sets, then knocked the RNA down in liver cancer cells.
NRAV was consistently overexpressed in tumors over normal liver, and higher levels tracked with nastier clinical features and poorer overall survival. As a diagnostic marker it discriminated cancer from normal tissue with an AUC of 0.901 on the standard scale. Tumors rich in NRAV also showed reduced CD8 T cell presence, tying the marker to an immune-colder microenvironment, and silencing it blunted malignant behavior in vitro.
Catalog record
| CREATOR | Xingbao Fang, Yan Cai, Zhaojun Li, Xiongbing Peng, Shaohua Yang, Zhuoyu Zhao, Yuehong Li |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 39 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |