Efficacy and safety of darolutamide plus androgen-deprivation therapy in Black patients with metastatic hormone-sensitive prostate cancer from the phase 3 ARANOTE trial
Quoc-Dien Trinh, Daniel J. George, Neal Shore, Egils Vjaters, David Olmos, Andrea Juliana P. de Santana Gomes, Augusto Cesar de Andrade Mota, Natasha Littleton, Shankar Srinivasan, Frank Verholen, Kunhi Parambath Haresh, Fred Saad · 2026
Read Efficacy and safety of darolutamide plus androgen-deprivation therapy in Black patients with metastatic hormone-sensitive prostate cancer from the phase 3 ARANOTE trial by Quoc-Dien Trinh, Daniel J. George, Neal Shore, Egils Vjaters, David Olmos, Andrea Juliana P. de Santana Gomes, Augusto Cesar de Andrade Mota, Natasha Littleton, Shankar Srinivasan, Frank Verholen, Kunhi Parambath Haresh, Fred Saad (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13473017.txt.
Description
Quoc-Dien Trinh and colleagues share 2026 results for Black patients in a large prostate cancer drug trial called ARANOTE. The full trial enrolled 669 men whose cancer had spread but still responded to hormone treatment. Sixty-five of those men were Black, and they received either darolutamide plus hormone therapy or a placebo plus hormone therapy. The drug is taken by mouth twice a day.
In this smaller group, adding darolutamide cut the risk of scan-based worsening or death by about half. That gain matched what the full trial found for all patients combined. Side effects stayed low and were much like those in the wider group. Readers get focused evidence for a group often left out of cancer trials.
Catalog record
| CREATOR | Quoc-Dien Trinh, Daniel J. George, Neal Shore, Egils Vjaters, David Olmos, Andrea Juliana P. de Santana Gomes, Augusto Cesar de Andrade Mota, Natasha Littleton, Shankar Srinivasan, Frank Verholen, Kunhi Parambath Haresh, Fred Saad |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 11362 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |