Three-dimensional mapping of intact ovaries reveals the aging dynamics of the ovarian reserve
Arturo D’Angelo, Daniel Franco-Barranco, Marco Musy, Juan Manuel Duran, James Sharpe, Nicholas Stroustrup, Ignacio Arganda-Carreras, Elvan Böke · 2026
Read Three-dimensional mapping of intact ovaries reveals the aging dynamics of the ovarian reserve by Arturo D’Angelo, Daniel Franco-Barranco, Marco Musy, Juan Manuel Duran, James Sharpe, Nicholas Stroustrup, Ignacio Arganda-Carreras, Elvan Böke (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13472977.txt.
Description
Female fertility depends on a finite pool of oocytes that depletes during aging1,2, yet the spatiotemporal dynamics of this depletion remain poorly understood. Traditional methods obscure the three-dimensional architecture of the ovary, limiting quantitative insights. Here we combine light-sheet microscopy, artificial intelligence-driven segmentation and mathematical modeling to map over 85,000 oocytes in whole ovaries across the reproductive lifespan in mouse.
Catalog record
| CREATOR | Arturo D’Angelo, Daniel Franco-Barranco, Marco Musy, Juan Manuel Duran, James Sharpe, Nicholas Stroustrup, Ignacio Arganda-Carreras, Elvan Böke |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 59 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |