Biological aging and generational shifts in early-onset cancer risk
Ruiyi Tian, Xiaoyu Zong, Duo Ren, Stefani Tica, Daniel Hong, Oluseye Oduyale, Jason D. Buenrostro, Ramaswamy Govindan, Yin Cao · 2026
Read Biological aging and generational shifts in early-onset cancer risk by Ruiyi Tian, Xiaoyu Zong, Duo Ren, Stefani Tica, Daniel Hong, Oluseye Oduyale, Jason D. Buenrostro, Ramaswamy Govindan, Yin Cao (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13472952.txt.
Description
Ruiyi Tian and colleagues link in 2026 faster biological aging in younger generations to the global rise in early onset cancer. Among more than one hundred fifty four thousand young adults in the UK Biobank, a blood based aging measure called PhenoAge climbed across birth cohorts. It rose most for those born in the late sixties and early seventies, measured against the earliest cohort. Faster aging tracked with higher early onset solid cancer risk, driven by lung, gut, and uterine cancers.
The link survived adjustment for inherited aging and cancer risk. Two other aging measures told the same story, and a United States cohort of about ten thousand partly confirmed it. Protein based organ aging sharpened the picture. Immune aging tied to early lung cancer, and fat tissue aging tied to early colorectal cancer. The authors propose age gap as a prevention target.
Catalog record
| CREATOR | Ruiyi Tian, Xiaoyu Zong, Duo Ren, Stefani Tica, Daniel Hong, Oluseye Oduyale, Jason D. Buenrostro, Ramaswamy Govindan, Yin Cao |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 58184 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |