Pathophysiological and immunological characterization of a murine excisional wound infection model for cutaneous Mycobacterium abscessus infection
Yuri Jung, Connor Wood, Joong-Yub Kim, Nakwon Kwak, Taek Soo Kim, Jae-Joon Yim, Siyeon Yang · 2026
Read Pathophysiological and immunological characterization of a murine excisional wound infection model for cutaneous Mycobacterium abscessus infection by Yuri Jung, Connor Wood, Joong-Yub Kim, Nakwon Kwak, Taek Soo Kim, Jae-Joon Yim, Siyeon Yang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13472947.txt.
Description
Jung and colleagues report a 2026 study building a mouse model for skin infection by Mycobacterium abscessus, a fast-growing bacterium that causes chronic, hard-to-treat wounds. Existing animal models inject the germ under intact skin, which poorly mimics real infection through broken skin. The team infected open excision wounds instead and compared the two routes in mice.
Wound infection produced persistent lesions whose tissue pattern matched human disease: pyogranulomatous inflammation, with foamy macrophages and giant fused cells around the germs. Lesions lasted and could be sampled for bacteria counts, local signal molecules, and blood profiles over time. Subcutaneous injection gave a weaker match. A faithful skin model matters because this germ resists many antibiotics; testing new drugs in a model that behaves like human wounds raises the odds that results carry over to patients.
Catalog record
| CREATOR | Yuri Jung, Connor Wood, Joong-Yub Kim, Nakwon Kwak, Taek Soo Kim, Jae-Joon Yim, Siyeon Yang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 44 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |