The genetic architecture of fibromyalgia across 2.5 million individuals
Isabel Kerrebijn, Gyda Bjornsdottir, Keon Arbabi, Lea Urpa, Hele Haapaniemi, Gudmar Thorleifsson, Lilja Stefansdottir, Stephan Frangakis, Jesse Valliere, Lovemore Kunorozva, Erik Abner, Caleb Ji, Markus Kangur, Bitten Aagaard, Henning Bliddal, Søren Brunak, Mie T Bruun, Maria Didriksen, Christian Erikstrup, Sarah Finer, Arni J Geirsson, Daniel F Gudbjartsson, Thomas F Hansen, David van Heel, Ingileif Jonsdottir, Stacey Knight, Kirk U Knowlton, Christina Mikkelsen, Lincoln D Nadauld, Thorunn A Olafsdottir, Sisse R Ostrowski, Ole B V Pedersen, Saedis Saevarsdottir, Astros T Skuladottir, Erik Sørensen, Hreinn Stefansson, Patrick Sulem, Olafur A Sveinsson, Gudny E Thorlacius, Unnur Thorsteinsdottir · 2026
Read The genetic architecture of fibromyalgia across 2.5 million individuals by Isabel Kerrebijn, Gyda Bjornsdottir, Keon Arbabi, Lea Urpa, Hele Haapaniemi, Gudmar Thorleifsson, Lilja Stefansdottir, Stephan Frangakis, Jesse Valliere, Lovemore Kunorozva, Erik Abner, Caleb Ji, Markus Kangur, Bitten Aagaard, Henning Bliddal, Søren Brunak, Mie T Bruun, Maria Didriksen, Christian Erikstrup, Sarah Finer, Arni J Geirsson, Daniel F Gudbjartsson, Thomas F Hansen, David van Heel, Ingileif Jonsdottir, Stacey Knight, Kirk U Knowlton, Christina Mikkelsen, Lincoln D Nadauld, Thorunn A Olafsdottir, Sisse R Ostrowski, Ole B V Pedersen, Saedis Saevarsdottir, Astros T Skuladottir, Erik Sørensen, Hreinn Stefansson, Patrick Sulem, Olafur A Sveinsson, Gudny E Thorlacius, Unnur Thorsteinsdottir (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13472937.txt.
Description
Isabel Kerrebijn leads a very large genetics team mapping in 2026 the inherited architecture of fibromyalgia across more than two and a half million people. This chronic widespread pain syndrome, bundled with fatigue and unrefreshing sleep, has resisted biological explanation. Eleven cohorts contributed about fifty five thousand cases and two and a half million controls to a multi ancestry genome scan.
Twenty six risk regions emerged. The strongest signal sat in the gene that causes Huntington disease when mutated, and partner genes pointed to brain roles, from wiring to dopamine signaling. Inherited influence concentrated in brain tissue and neural cell types alone. Genetic correlations ran high with back pain, trauma stress, and irritable bowel, above point seven for each. Men and women, despite very different prevalence, shared nearly identical genetic architecture.
Catalog record
| CREATOR | Isabel Kerrebijn, Gyda Bjornsdottir, Keon Arbabi, Lea Urpa, Hele Haapaniemi, Gudmar Thorleifsson, Lilja Stefansdottir, Stephan Frangakis, Jesse Valliere, Lovemore Kunorozva, Erik Abner, Caleb Ji, Markus Kangur, Bitten Aagaard, Henning Bliddal, Søren Brunak, Mie T Bruun, Maria Didriksen, Christian Erikstrup, Sarah Finer, Arni J Geirsson, Daniel F Gudbjartsson, Thomas F Hansen, David van Heel, Ingileif Jonsdottir, Stacey Knight, Kirk U Knowlton, Christina Mikkelsen, Lincoln D Nadauld, Thorunn A Olafsdottir, Sisse R Ostrowski, Ole B V Pedersen, Saedis Saevarsdottir, Astros T Skuladottir, Erik Sørensen, Hreinn Stefansson, Patrick Sulem, Olafur A Sveinsson, Gudny E Thorlacius, Unnur Thorsteinsdottir |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 99 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |