ctDNA-derived copy-number signatures associated with immune checkpoint inhibitor resistance beyond PD-L1 and TMB in advanced NSCLC
Pedro Gonzalez Santa-Catalina, Luis Posado-Domínguez, Álvaro López-Gutiérrez, Edel del Barco Morillo, Juan Carlos Redondo-González, Noelia Egido-Iglesias, Laura Corvo-Félix, Isabel Muela Bravo, Aline Rodrigues-Françoso, Lorena Bellido-Hernández, Emilio Fonseca-Sánchez, Juan Jesús Cruz-Hernández, Juan Manuel Corchado, Juan Luis García Hernández, Alejandro Olivares-Hernández · 2026
Read ctDNA-derived copy-number signatures associated with immune checkpoint inhibitor resistance beyond PD-L1 and TMB in advanced NSCLC by Pedro Gonzalez Santa-Catalina, Luis Posado-Domínguez, Álvaro López-Gutiérrez, Edel del Barco Morillo, Juan Carlos Redondo-González, Noelia Egido-Iglesias, Laura Corvo-Félix, Isabel Muela Bravo, Aline Rodrigues-Françoso, Lorena Bellido-Hernández, Emilio Fonseca-Sánchez, Juan Jesús Cruz-Hernández, Juan Manuel Corchado, Juan Luis García Hernández, Alejandro Olivares-Hernández (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13472933.txt.
Description
Gonzalez Santa-Catalina and colleagues explored in 2026 whether patterns in tumor DNA floating in blood can predict who resists immune checkpoint drugs in advanced lung cancer. Standard markers, PD-L1 levels and mutation burden, leave much of the variation unexplained. The team sequenced blood tumor DNA from 37 patients starting first-line immune therapy.
Median progression-free survival was nine months and overall survival twenty months in this group. Mutation burden looked similar in patients with good and poor outcomes. Copy-number signatures, which summarize large gains and losses in chromosomes, separated the outcome groups most clearly. One signature tied to unstable genomes ran higher in poor-outcome patients, while another marked the best responders. None survived strict statistical correction, so the authors call the work hypothesis-generating.
Catalog record
| CREATOR | Pedro Gonzalez Santa-Catalina, Luis Posado-Domínguez, Álvaro López-Gutiérrez, Edel del Barco Morillo, Juan Carlos Redondo-González, Noelia Egido-Iglesias, Laura Corvo-Félix, Isabel Muela Bravo, Aline Rodrigues-Françoso, Lorena Bellido-Hernández, Emilio Fonseca-Sánchez, Juan Jesús Cruz-Hernández, Juan Manuel Corchado, Juan Luis García Hernández, Alejandro Olivares-Hernández |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 44 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |