Extracellular vesicles in heart failure: bridging pathogenic insights, diagnostic utility, and therapeutic applications
Tingting Li, Jin Yang, Xinyue Ding, Zhen Qi, Zongjun Liu · 2026
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Description
Li and colleagues reviewed in 2026 the roles of extracellular vesicles in heart failure. Vesicles are tiny membrane parcels cells release, carrying proteins, fats, and RNA messages between cells. The review covers how vesicles shape inflammation, energy failure in heart cells, muscle thickening, scarring, cell death, and blood vessel growth in the failing heart. It also assesses vesicles as blood biomarkers and as treatments.
Vesicle contents mirror the state of their parent cells, so their cargo can signal disease stage. Stem cell-derived vesicles show protective effects in early studies, and engineered vesicles can ferry drugs or RNA to target tissue. The authors also discuss how current heart failure drugs interact with vesicle pathways. They argue vesicles connect mechanism to clinic: one entity serving as messenger, marker, and medicine.
Catalog record
| CREATOR | Tingting Li, Jin Yang, Xinyue Ding, Zhen Qi, Zongjun Liu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 98 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |