Systemic and local chronic inflammation and hormone disposition promote a tumor-permissive environment for breast cancer in older women
Neil Carleton, Alexander Chih-Chieh Chang, Sanghoon Lee, Ruxuan Li, Jian Zou, Daniel D. Brown, Jagmohan Hooda, Jian Chen, Rahul Kumar, Linda R. Klei, Lora H. Rigatti, Joseph Newsome, Dixcy Jaba Sheeba John Mary, Jennifer M. Atkinson, Raymond E. West, Thomas D. Nolin, Patrick J. Oberly, Ziyu Huang, Donald Poirier, Emilia J. Diego, Peter C. Lucas, George C. Tseng, Michael T. Lotze, Priscilla F. McAuliffe, Ioannis K. Zervantonakis, Steffi Oesterreich, Adrian V. Lee · 2026
Read Systemic and local chronic inflammation and hormone disposition promote a tumor-permissive environment for breast cancer in older women by Neil Carleton, Alexander Chih-Chieh Chang, Sanghoon Lee, Ruxuan Li, Jian Zou, Daniel D. Brown, Jagmohan Hooda, Jian Chen, Rahul Kumar, Linda R. Klei, Lora H. Rigatti, Joseph Newsome, Dixcy Jaba Sheeba John Mary, Jennifer M. Atkinson, Raymond E. West, Thomas D. Nolin, Patrick J. Oberly, Ziyu Huang, Donald Poirier, Emilia J. Diego, Peter C. Lucas, George C. Tseng, Michael T. Lotze, Priscilla F. McAuliffe, Ioannis K. Zervantonakis, Steffi Oesterreich, Adrian V. Lee (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13472878.txt.
Description
Neil Carleton leads a twenty seven author team modeling in 2026 how aging, hormones, and chronic inflammation conspire to make breast tissue permissive for estrogen driven tumors in older women. Estrogen receptor positive cancer is the commonest breast cancer type and rises with age, yet the aging tissue logic behind it stayed murky. An aged rat model showed age shifted tumor development and immune features, and patient samples filled in the human side.
Older patients blood carried an estrone heavy estrogen pattern, and their tumors raised an enzyme that converts estrone into the stronger estradiol locally. Blocking that enzyme in organoids grown from older women tissue cut both conversion and growth programs. Their tumors also brimmed with a chemokine tied to suppressive macrophages. Hitting hormone and chemokine paths together blunted the macrophage shift in dishes.
Catalog record
| CREATOR | Neil Carleton, Alexander Chih-Chieh Chang, Sanghoon Lee, Ruxuan Li, Jian Zou, Daniel D. Brown, Jagmohan Hooda, Jian Chen, Rahul Kumar, Linda R. Klei, Lora H. Rigatti, Joseph Newsome, Dixcy Jaba Sheeba John Mary, Jennifer M. Atkinson, Raymond E. West, Thomas D. Nolin, Patrick J. Oberly, Ziyu Huang, Donald Poirier, Emilia J. Diego, Peter C. Lucas, George C. Tseng, Michael T. Lotze, Priscilla F. McAuliffe, Ioannis K. Zervantonakis, Steffi Oesterreich, Adrian V. Lee |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 111 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |