Amyloid-β modulates APOE ε4 effects on cognition but not on targeted structural or functional connectivity measures over 2 years in pre-dementia adults
Hongchun Wei, Tianhao Zhang, Zhigang Liang, Min Li, Min Kong, Maowen Ba · 2026
Read Amyloid-β modulates APOE ε4 effects on cognition but not on targeted structural or functional connectivity measures over 2 years in pre-dementia adults by Hongchun Wei, Tianhao Zhang, Zhigang Liang, Min Li, Min Kong, Maowen Ba (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13472819.txt.
Description
Wei and colleagues tracked in 2026 how the Alzheimer's risk gene APOE ε4 affects thinking decline depending on amyloid build-up. They followed seventy pre-dementia adults for two years with gene testing, brain scans, and cognition tests. The group came from the ADNI study. Analysis tested whether amyloid status changes the gene's effect on decline over time.
A significant three-way interaction emerged for global cognition: the gene's effect depended on amyloid status. Surprisingly, among amyloid-positive adults, gene carriers declined more slowly than non-carriers over the two years. In amyloid-negative adults, no such difference appeared. Brain volume and connectivity measures were also tracked in the hippocampus-auditory network. The authors frame the result as age- and pathology-dependent gene effects, not a simple risk story. They caution the sample is small and the window short.
Catalog record
| CREATOR | Hongchun Wei, Tianhao Zhang, Zhigang Liang, Min Li, Min Kong, Maowen Ba |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 44 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |