A novel role of the TNF-α/p65/IRF1 axis in aggravating rheumatoid arthritis through the induction of fibroblast-like synoviocytes pyroptosis
Qian Jia, Xiuli Zhang, Li Jiang, Zhenchun Zhang, Zunzhong Li, Yuling Wang, Peng Yan · 2026
Read A novel role of the TNF-α/p65/IRF1 axis in aggravating rheumatoid arthritis through the induction of fibroblast-like synoviocytes pyroptosis by Qian Jia, Xiuli Zhang, Li Jiang, Zhenchun Zhang, Zunzhong Li, Yuling Wang, Peng Yan (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13472745.txt.
Description
Jia and colleagues report a 2026 study of a gene switch that worsens rheumatoid arthritis by driving a fiery cell death in joint lining cells. The switch, IRF1, was measured in patient joint tissue, arthritic mouse joints, and cultured lining cells stimulated with the inflammatory signal TNF-alpha. The team then blocked IRF1 and mapped which genes it controls.
IRF1 ran high in rheumatoid tissue and in stimulated cells. Suppressing it cut pyroptosis, the inflammatory bursting death, and lowered the inflammatory output of the lining cells. Gene mapping showed how the TNF signal, through its p65 relay, switches IRF1 on. Treating arthritic mice by modulating IRF1 eased disease severity. The chain gives drug hunters a defined axis to interrupt in a disease where lining cells act as aggressors, not victims.
Catalog record
| CREATOR | Qian Jia, Xiuli Zhang, Li Jiang, Zhenchun Zhang, Zunzhong Li, Yuling Wang, Peng Yan |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 67 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |