Self‐Amplified Activatable Fluorescent Probe for Early Diagnosis of Acute Kidney Injury and High‐Throughput Screening of Natural Protectants
Yahui Chen, Meihong Liu, Mengchao Ding, Ye Liu, Chuanxu Zhu, Mingye Gong, Zhixuan Huang, Yi Zhang, Wei Xue, Youyong Yuan, Kewei Wang · 2026
Read Self‐Amplified Activatable Fluorescent Probe for Early Diagnosis of Acute Kidney Injury and High‐Throughput Screening of Natural Protectants by Yahui Chen, Meihong Liu, Mengchao Ding, Ye Liu, Chuanxu Zhu, Mingye Gong, Zhixuan Huang, Yi Zhang, Wei Xue, Youyong Yuan, Kewei Wang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13472104.txt.
Description
Yahui Chen and co-authors build a glowing probe that spots early kidney injury and screens plant protectants, in work from 2026. Acute kidney injury is often caught late by standard blood tests. A fast, sensitive signal could open a window for early treatment.
The probe rides inside tiny carriers dressed to home to injured kidney tubes. Harm-linked oxygen radicals switch the probe on, and it then splits to release four glowing parts at once. That self-amplifying trick gives a very low detection floor. In mice, the probe lit up drug-induced injury at twelve hours, well before standard tests. The team also used it to screen natural compounds for kidney protection.
Catalog record
| CREATOR | Yahui Chen, Meihong Liu, Mengchao Ding, Ye Liu, Chuanxu Zhu, Mingye Gong, Zhixuan Huang, Yi Zhang, Wei Xue, Youyong Yuan, Kewei Wang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 61 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |